ODCs

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4 OMIM references -
3 associated genes
26 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2

1 associated gene
4 signs/symptoms

Familial thrombocytosis

Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	JAK2	(0.85)	KIT

Citations in the biomedical literature:

Familial thrombocytosis		Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease
	Synonym(s): - Familial thrombocythemia - Hereditary thrombocythemia		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): (no data available)		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: adulthood Average age of death: - Type of inheritance: sporadic

	External references: 4 OMIM references - No MeSH references		External references: No OMIM references No MeSH references


COMMON SIGNS	- Acute leukemia - Myeloproliferative syndrome / chronic leukemia

Familial thrombocytosis		Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease
	Very frequent - Arterial embolism / thrombosis - Autosomal dominant inheritance - Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding - Platelet disorders / thrombopathies - Platelets shape anomalies - Venous thrombosis / phlebitis / thrombophlebitis Frequent - Acute ischemia of the lower limbs - Acute ischemic syndrome - Facial pain / cephalalgia / migraine - Hyperhidrosis / increased sweating - Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness - Pruritus / itching - Splenomegaly - Thoracic / chest pain - Transient cerebral ischemia / stroke Occasional - Abnormal visual field / hemianopsia / hemianopia / scotoma / visual peripheral rim - Dizziness - Early death / lethality - Elocution disorders / dysarthria / dysphonia - Myelodysplastic syndrome - Pulmonary hypertension - Seizures / epilepsy / absences / spasms / status epilepticus - Spontaneous abortions - Weight loss / loss of appetite / break in weight curve / general health alteration		Very frequent - Eosinophils anomalies / hypereosinophilia - Mastocytosis